• Why Cettire, Collins Foods, Liontown, and Northern Star shares are dropping today

    A male investor wearing a blue shirt looks off to the side with a miffed look on his face as the share price declines.

    In afternoon trade, the S&P/ASX 200 Index (ASX: XJO) is out of form and on course to record a disappointing decline. At the time of writing, the benchmark index is down 1.05% to 7,755.6 points.

    Four ASX shares that are falling more than most today are listed below. Here’s why they are dropping:

    Cettire Ltd (ASX: CTT)

    The Cettire share price is down 4% to $1.07. Investors continue to sell this online luxury products retailer after it warned that “the operating environment within global online luxury has become more challenging” with heightened levels of discounting. Not even a bullish broker note out of Bell Potter has been able to stop Cettire’s shares from hitting a new 52-week low today. Its analysts have retained their buy rating with a reduced price target of $2.60. This is more than double where the embattled company’s shares are currently trading.

    Collins Foods Ltd (ASX: CKF)

    The Collins Foods share price is down 7% to $9.27. This morning, analysts at Citi responded to the quick service restaurant operator’s FY 2024 results by retaining their sell rating and $10.60 price target. Its analysts highlight that the company is currently battling with some challenging market conditions. It was also disappointed to see that management no longer expects margin improvements in the new financial year. Instead, its margins are likely to soften.

    Liontown Resources Ltd (ASX: LTR)

    The Liontown Resources share price is down 5% to 85.2 cents. This appears to have been driven by broad weakness in the lithium industry today. Investors have been selling lithium stocks after the price of the battery making ingredient continued to fall. In addition, analysts at Barrenjoey are feeling bearish about Liontown Resources. According to a note, this morning the broker has downgraded the lithium developer’s shares to an underweight rating. Liontown Resources’ shares hit a multi-year low today.

    Northern Star Resources Ltd (ASX: NST)

    The Northern Star Resources share price is down 3% to $12.97. This may have been driven by the release of inflation data in Australia and Canada. Locally, our inflation was stronger than expected in May. Whereas over in Canada, it reported an increase in inflation after cutting interest rates. Investors may believe this is going to lead to the Reserve Bank of Australia and the US Federal Reserve pushing back their interest rate cut plans. This could be bad news for the gold price.

    The post Why Cettire, Collins Foods, Liontown, and Northern Star shares are dropping today appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Collins Foods Limited right now?

    Before you buy Collins Foods Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Collins Foods Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Citigroup is an advertising partner of The Ascent, a Motley Fool company. Motley Fool contributor James Mickleboro has positions in Collins Foods. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has recommended Cettire and Collins Foods. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • Why A2 Milk, Actinogen Medical, Karoon Energy, and Race Oncology shares are rising

    a man in a business suite throws his arms open wide above his head and raises his face with his mouth open in celebration in front of a background of an illuminated board tracking stock market movements.

    The S&P/ASX 200 Index (ASX: XJO) is having a tough time on Wednesday after a stronger than expected inflation reading. In afternoon trade, the benchmark index is down 1% to 7,758.4 points.

    Four ASX shares that are not letting that hold them back are listed below. Here’s why they are rising:

    A2 Milk Company Ltd (ASX: A2M)

    The A2 Milk share price is up over 2% to $6.66. This appears to have been driven by a broker note out of Citi this morning. In response to very positive industry data, the broker is feeling confident about the company’s outlook. Particularly given the improving birth rate outlook in China and its belief that domestic brands are not going to limit its growth. As a result, it has reaffirmed its buy rating and $7.85 price target on its shares. This implies potential upside of almost 18% for investors over the next 12 months.

    Actinogen Medical Ltd (ASX: ACW)

    The Actinogen Medical share price is up 19% to 3.7 cents. This morning, this biotech announced that positive trial data relating to its Xanamem product in patients with elevated blood pTau. The company’s chief medical officer, Dr Dana Hilt, said: “To our knowledge Xanamem is the first drug of this class to have such compelling data. The previously published PET study highlighted just how effective Xanamem is at reaching its target enzyme in the brain at safe and well tolerated doses of 5 and 10 mg/day. No other inhibitor of 11β-HSD1 has ever demonstrated robust central nervous system target engagement in this direct way.”

    Karoon Energy Ltd (ASX: KAR)

    The Karoon Energy share price is up 2% to $1.80. This may be a delayed reaction to the energy company’s drilling and operational update yesterday. That update confirmed that the Bauna Project restarted production on 11 June as scheduled. In addition, it advised that Who Dat production is currently averaging over 40,000 barrels of oil equivalent (boe) per day on a gross basis. As a result, Karoon Energy expects Who Dat production for the quarter ended 30 June 2024 to be approximately 0.8 million boe.

    Race Oncology Ltd (ASX: RAC)

    The Race Oncology share price is up 6% to $1.81. Investors have been buying this clinical stage biopharmaceutical company’s shares following the release of a positive announcement relating to its RC220 bisantrene formulation. The company is advancing RC220 to address the high unmet needs of patients across multiple oncology indications. According to the release, toxicology and safety pharmacology studies showed no unexpected or unacceptable toxicities. This means that the completed data package supports the use of RC220 bisantrene in human clinical trials.

    The post Why A2 Milk, Actinogen Medical, Karoon Energy, and Race Oncology shares are rising appeared first on The Motley Fool Australia.

    Should you invest $1,000 in The A2 Milk Company Limited right now?

    Before you buy The A2 Milk Company Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and The A2 Milk Company Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Citigroup is an advertising partner of The Ascent, a Motley Fool company. Motley Fool contributor James Mickleboro has no position in any of the stocks mentioned. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has recommended A2 Milk. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • The ASX 200 just plummeted on May’s inflation figures. Here’s why

    A man holds his head in his hands, despairing at the bad result he's reading on his computer.

    After closing up 1.4% on Tuesday, the S&P/ASX 200 Index (ASX: XJO) looks ready to give back most of those gains today.

    The benchmark index was down 0.5% at 11.30am AEST.

    Then, the Australian Bureau of Statistics (ABS) released May’s Australian inflation data.

    In the minutes after the latest consumer price index (CPI) figures hit the wires, the ASX 200 tumbled another 0.6% to be down 1.1% in intraday trading at the time of writing.

    Here’s why investors just got a case of the jitters.

    What’s pressuring the ASX 200?

    Investors, mortgage holders, and many other Aussies have been holding their breath in hopes that the Reserve Bank of Australia (RBA) will cut the official interest rate from the current 4.35% after hiking 13 times since May 2022.

    But May’s inflation print looks to have not only pushed any potential interest rate cuts into 2025 but also may have opened the door to another RBA rate hike. And that’s not what ASX 200 investors were hoping to hear.

    Consensus forecasts were for Aussie inflation to reach 3.8% on an annualised basis, up from 3.6% in April.

    National Australia Bank Ltd (ASX: NAB) was slightly more optimistic, earlier this week forecasting a 3.6% year-on-year inflation increase.

    Unfortunately, as you can guess by the big drop in the ASX 200, the data surprised to the upside.

    According to the latest data from the ABS, the monthly CPI indicator rose 4.0% in the 12 months to May.

    Commenting on the uptick in inflation, Michelle Marquardt, ABS head of prices statistics, noted that underlying inflation, which takes out volatile items, edged lower.

    According to Marquardt:

    CPI inflation is often impacted by items with volatile price changes like automotive fuel, fruit and vegetables, and holiday travel. It can be helpful to exclude these items from the headline CPI to provide a view of underlying inflation, which was 4.0% in May, down from 4.1 per cent in April.

    The biggest contributors to the increase in CPI inflation in May were housing (up 5.2%), food and non-alcoholic beverages (up 3.3%), transport (up 4.9%), and alcohol and tobacco (up 6.7%).

    And inflation might have run even higher if not for government energy rebates.

    “The introduction of the Energy Bill Relief Fund rebates from July 2023 has mostly offset electricity price rises from annual price reviews in the same month,” Marquardt said. “Excluding the rebates, electricity prices would have risen 14.5% in the 12 months to May 2024.”

    With those rebates factored in electricity prices rose 6.5% in the 12 months to May, up from 4.2% in April.

    But don’t go selling all your stocks just yet!

    Despite sticky inflation and interest rates at levels not seen since 2011, the ASX 200 has gained 10% over the past 12 months. If you’re not sure which ASX stocks have the best potential in the current economic environment, be sure to get some expert advice.

    The post The ASX 200 just plummeted on May’s inflation figures. Here’s why appeared first on The Motley Fool Australia.

    Wondering where you should invest $1,000 right now?

    When investing expert Scott Phillips has a stock tip, it can pay to listen. After all, the flagship Motley Fool Share Advisor newsletter he has run for over ten years has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    Scott just revealed what he believes could be the ‘five best ASX stocks’ for investors to buy right now. We believe these stocks are trading at attractive prices and Scott thinks they could be great buys right now…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor Bernd Struben has no position in any of the stocks mentioned. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • I think this ASX 200 stock is a tremendous bargain today

    a man wearing a hard hat, a shirt and a tie, lays a brick on a wall he is building with a look of happy joy on his face.

    The S&P/ASX 200 Index (ASX: XJO) stock Brickworks Limited (ASX: BKW) looks like a great opportunity in my opinion.

    Not only is it a wonderful business with excellent assets, but it’s trading at a large discount to those assets.

    When you can buy a good company at an appealing price-to-book ratio, it can lead to pleasing investment returns over time if the business keeps growing its underlying value. On top of that, I believe Brickworks is a solid ASX 200 dividend stock as well.

    Brickworks’ excellent assets

    The company has three areas – investments, property and building products.

    In the investments segment, the key asset is 26.1% of Washington H. Soul Pattinson and Co. Ltd (ASX: SOL). Soul Patts is a large investment house that’s invested in sectors like telecommunications, resources, financial services, swimming schools and agriculture. Brickworks also owns 14.8% of bricklaying robot company FBR Ltd (ASX: FBR).

    Brickworks owns various property assets, including land and manufacturing property, in its own name. It also owns half of a manufacturing property trust that owns some of the buildings used by Brickworks’ building products businesses and 50% of an industrial property trust.

    The ASX 200 stock occasionally sells excess land into the industrial property trust, where partner Goodman Group (ASX: GMG) builds large, advanced warehouses on the land. This improves the value of the land and unlocks excellent rental income for Brickworks and Goodman. The property portfolio within the joint venture trust is steadily growing.

    The industrial property trust is benefiting from tailwinds, including online shopping’s increasing demand for ‘list-mile’ logistics and warehousing. There’s also growing demand for sophisticated and higher-value facilities (including robotics and multi-storey).

    Brickworks has building product operations in Australia and the US. In Australia, it’s the biggest brickmaker and is also involved with roofing, masonry and stone, specialised building systems, cement, and timber battens. In the US, it’s the largest brickmaker in the northeast of the country. Brickworks has assets related to those operations in both countries.

    Large discount with the ASX 200 stock

    At 31 January, the business reported it had $1.95 billion of net tangible assets (NTA) relating to the property trusts, $608 million of NTA relating to building products, $615 million of net debt and $384 million of 100%-owned development land, with an ‘as is’ market value.

    Currently, 26.1% of Soul Patts’ market capitalisation is $3.1 billion.

    Therefore, the latest known inferred value of those assets, excluding deferred tax liabilities, is around $5.4 billion, so Brickworks shares are trading at roughly a 23% discount to this at its current market capitalisation.

    With the high-quality nature of the underlying assets, particularly the property and investments, I think the size of the discount is unwarranted and presents compelling value. Brickworks can grow its value further as the development land is utilised for more industrial properties, it improves its building product operations, and it benefits from the compounding of Soul Patts’ investment portfolio.

    The ASX 200 stock can work as a buy-and-hold investment with its impressive dividend, which hasn’t been cut for almost 50 years. Brickworks currently has a grossed-up dividend yield of 3.5%.

    The post I think this ASX 200 stock is a tremendous bargain today appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Brickworks Limited right now?

    Before you buy Brickworks Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Brickworks Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor Tristan Harrison has positions in Brickworks and Washington H. Soul Pattinson and Company Limited. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has positions in and has recommended Brickworks, Goodman Group, and Washington H. Soul Pattinson and Company Limited. The Motley Fool Australia has positions in and has recommended Brickworks and Washington H. Soul Pattinson and Company Limited. The Motley Fool Australia has recommended Goodman Group. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • 3 ASX 200 mining shares just downgraded by top brokers

    Three miners looking at a tablet.

    Three S&P/ASX 200 Index (ASX: XJO) mining shares just had their outlooks cut by leading brokers.

    All three have a primary focus on different metals.

    Namely gold, lithium and iron ore.

    Yet the brokers expect all three could face some headwinds in the year ahead.

    Which stocks are we on about?

    Read on!

    (Broker data courtesy of The Australian.)

    Three ASX 200 mining shares with reduced outlooks

    Gold miner Northern Star Resources Ltd (ASX: NST) is the first ASX 200 mining share to get hit with a broker downgrade.

    The Northern Star share price is down 2.7% today, with shares trading for $13.05 apiece. Despite coming under selling pressure since late April, shares in the ASX 200 gold miner remain up 4% over a year. Northern Star shares also trade on a fully franked trailing dividend yield of 2.3%.

    Now Barrenjoey has reduced its outlook for the big Aussie gold miner, cutting it to a neutral rating. However, with a $14.50 price target, the broker still foresees a potential upside of more than 11% from current levels.

    This brings us to the second ASX 200 mining share to be downgraded by a broker: iron ore giant Fortescue Ltd (ASX: FMG).

    The Fortescue share price is down 1.5% today at $21.33 a share. That sees the share price just about flat over the past 12 months, with the share price now having tumbled more than 27% in 2024. That pressure has largely come amid a big retrace in iron ore prices. The industrial metal kicked off 2024 trading above US$140 per tonne. Today, that same tonne is trading for around US$103.

    With dividends holding up and the share price dropping, Fortescue shares trade on a juicy, fully franked trailing dividend yield of 9.8%.

    Despite the big year-to-date fall, Barrenjoey believes the iron ore miner could continue to edge lower. The broker cut Fortescue’s share to an underweight rating with a $21.00 price target, about 1.5% below the current level.

    Liontown Resources Ltd (ASX: LTR) rounds off the list of ASX 200 mining shares getting socked with a broker downgrade.

    Shares in the lithium miner are taking a beating today, down 4.8% at 86 cents apiece. That sees the Liontown share price down a painful 70% since this time last year.

    And Barrenjoey isn’t forecasting any big turnaround in the year ahead. The broker cut Liontown shares to an underweight rating.

    The post 3 ASX 200 mining shares just downgraded by top brokers appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Fortescue Metals Group right now?

    Before you buy Fortescue Metals Group shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Fortescue Metals Group wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor Bernd Struben has no position in any of the stocks mentioned. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • Where to invest your Westpac dividends

    Yesterday was a good day for Westpac Banking Corp (ASX: WBC) shareholders.

    That’s because it was pay day!

    The banking giant rewarded its loyal shareholders with a fully franked 90 cents per share interim dividend.

    And while some shareholders may have opted to use the bank’s dividend reinvestment program, others may now be looking for somewhere to invest these dividends.

    Let’s look at two buy-rated ASX shares to consider snapping up:

    NextDC Ltd (ASX: NXT)

    The first option for your Westpac dividends could be NextDC. Morgans thinks that investors should snap up this data centre operator’s shares. So much so, it has the company on its best ideas list with an add rating and $19.00 price target. It commented:

    NXT should deliver another good set of results in FY24 with some upside risk to guidance, in our view. Structural demand for cloud and colocation remains incredibly strong. NXT’s new S3 and M3 data centres are now open. Consequently, we expect significant new customer wins over the next six-to-twelve months (including CSP options being exercised). Sales should drive the share price higher. NXT looks comfortably on-track to generate over $300m of EBITDA in the next three to five years.

    Woolworths Group Ltd (ASX: WOW)

    If you are on the lookout for defensive options and a source of income, then it could be worth taking a closer look at Woolworths. It is of course one of the big two supermarket operators in Australia.

    It could be a good option for those Westpac dividends based on what analysts at Goldman Sachs are saying. They currently have a conviction buy rating and $39.40 price target on its shares. The broker said:

    WOW is the largest supermarket chain in Australia with an additional presence in NZ, as well as selling general merchandise retail via Big W. We are Buy rated on the stock as we believe the business has among the highest consumer stickiness and loyalty among peers, and hence has strong ability to drive market share gains via its omni-channel advantage, as well as its ability to pass through any cost inflation to protect its margins, beyond market expectations. The stock is trading below its historical average (since 2018), and we see this as a value entry level for a high-quality and defensive stock.

    As for income, Goldman is expecting fully franked dividend yields in the region of 3% through to at least FY 2026.

    The post Where to invest your Westpac dividends appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Nextdc Limited right now?

    Before you buy Nextdc Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Nextdc Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor James Mickleboro has positions in Nextdc and Westpac Banking Corporation. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has positions in and has recommended Goldman Sachs Group. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • This tech stock is ‘one the highest quality companies on the ASX’

    If you want to grow your wealth in the share market, then investing in quality companies is always a good idea.

    After all, the cream always rises to the top.

    With that in mind, it could pay to listen to what one of Australia’s leading investment companies is saying about an ASX tech stock.

    Blackwattle Investment Partners has described this stock as “one the highest quality companies on the ASX.”

    Which ASX tech stock?

    The stock in question is cloud accounting platform provider Xero Ltd (ASX: XRO).

    According to the Blackwattle Mid Cap Quality fund, its strong recent performance has been underpinned partly by Xero’s high-flying shares.

    As at the end of May, the fund was up 16.95% over the past six months. This compares to 11.45% for its benchmark, which means a 5.5% outperformance.

    Commenting on the ASX tech stock, the investment company said:

    Xero was the largest positive contributor to performance during the month. XRO rose 11% in May, on the back of a very strong FY24 result and solid outlook. XRO is a market-leading, global accounting SaaS platform. XRO’s FY24 result showcased the benefits of the cultural change brought in by CEO Sukhinder Singh-Cassidy in early 2023, balancing top-line growth with profitability. XRO delivered a record EBITDA margin of 31% and free cash flow growth of over 280%, significantly beating market expectations.

    The good news is that Blackwattle still sees plenty of upside for Xero despite this outperformance. It adds:

    This result has cemented our view of XRO being one the highest quality companies on the ASX. We continue to see significant upside for XRO, as they continue their journey to being the market-leading, global accounting software for SMEs, while delivering strong financial metrics.

    Is anyone else bullish?

    Blackwattle isn’t alone with its bullish view on this ASX tech stock.

    Goldman Sachs is very bullish on the company and currently has a conviction buy rating and $164.00 price target on its shares. It said:

    We see Xero as very well-placed to take advantage of the digitisation of SMBs globally, driven by compelling efficiency benefits and regulatory tailwinds, with >100mn SMBs worldwide representing a >NZ$100bn TAM. Given the company’s pivot to profitable growth and corresponding faster earnings ramp, we see an attractive entry point into a global growth story with Xero our preferred large-cap technology name in ANZ – the stock is Buy rated.

    The post This tech stock is ‘one the highest quality companies on the ASX’ appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Xero Limited right now?

    Before you buy Xero Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Xero Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor James Mickleboro has positions in Xero. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has positions in and has recommended Goldman Sachs Group and Xero. The Motley Fool Australia has positions in and has recommended Xero. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • Guess which ASX healthcare stock is surging 15% on a ‘major milestone’

    Race Oncology Ltd (ASX: RAC) shares burst out of the gates on Wednesday morning.

    In early trade, the ASX healthcare stock was up as much as 15% to $1.96.

    The clinical stage biopharmaceutical company’s shares have eased back a touch since then. At the time of writing, they are up 7% to $1.83.

    Why is this ASX healthcare stock surging?

    The catalyst for this strong gain has been the release of a positive announcement relating to its RC220 bisantrene formulation.

    The company is advancing RC220 to address the high unmet needs of patients across multiple oncology indications.

    In October, Race Oncology contracted Attentive Science and Agilex Biolabs to undertake the regulatory-standard Good Laboratory Practice (GLP) non-clinical toxicology and safety pharmacology studies required to advance RC220 bisantrene into human clinical trials.

    These studies aimed to demonstrate in two animal species that RC220 bisantrene is safe and amenable to administration via peripheral IV infusion in humans. In addition, they aimed to establish an acceptable starting dose for Phase I clinical studies.

    According to the release, this GLP program has been delivered on time and on-budget.

    More importantly, the GLP toxicology and safety pharmacology studies showed no unexpected or unacceptable toxicities. As a result, management notes that the completed data package supports the use of RC220 bisantrene in human clinical trials.

    The company advised that three doses of RC220 bisantrene were administered via peripheral veins. These were low, medium and high doses, which reflect the expected dose-range in humans. Pleasingly, these doses showed similar systemic effects to those seen when using the historical bisantrene formulation administered via a central line.

    Examination of the animals after a four-week post-dose recovery period showed that all observed toxicities were reversible. Importantly, there were no formulation-specific adverse macroscopic or histological findings at the sites of infusion.

    What now?

    Data from these studies will be used to support regulatory and ethics submissions for evaluation of RC220 bisantrene in human clinical trials. This includes the upcoming Phase 1a/1b trial in Australia, Hong Kong, and South Korea, an investigator-sponsored Phase 1/2 AML trial, and a US FDA Investigational New Drug (IND) application in 2025.

    The ASX healthcare stock’s CEO, Dr Daniel Tillett, described the news as “another major milestone” for the company. He commented:

    Receiving clear confirmation of the safety of RC220 bisantrene in these studies and identifying a suitable starting dose for our upcoming trial is another major milestone in bringing our new drug product to cancer patients. I congratulate and thank the Race preclinical team, Attentive Science and Agilex Biolabs for completing these studies on time and on-budget.

    Following today’s gain, Race Oncology’s shares are now up approximately 115% since the start of the year.

    The post Guess which ASX healthcare stock is surging 15% on a ‘major milestone’ appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Race Oncology Limited right now?

    Before you buy Race Oncology Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Race Oncology Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor James Mickleboro has no position in any of the stocks mentioned. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

  • Lauren Boebert’s carpetbagging victory is a vindication of her attention-grabbing antics

    Rep. Lauren Boebert outside of Trump's hush money trial in New York last month.
    Rep. Lauren Boebert outside of Trump's hush money trial in New York last month.

    • Rep. Lauren Boebert won a GOP primary for a district she only moved into this year.
    • That's despite facing charges of "carpetbagging" and her embarrassing "Beetlejuice" scandal.
    • She triumphed against a crowded field of local candidates on the strength of her notoriety.

    Rep. Lauren Boebert managed to pull it off.

    The controversial congresswoman won a crowded GOP primary in Colorado's 4th congressional district on Tuesday, according to Decision Desk HQ and the Associated Press.

    That's despite her only having lived there since the beginning of this year. Given that the district is far safer than the one she abandoned, Boebert is now on a glide path toward reelection in November.

    In pulling off a win, Boebert managed to overcome significant headwinds, including the lingering embarrassment of her "Beetlejuice" scandal, fatigue with aspects of her political persona, and accusations of being a "carpetbagger."

    One recent poll gives us a big clue as to how she pulled it off: name recognition.

    Love her or hate her, you probably know who Lauren Boebert is, especially if you live in Colorado.

    Polling from Kaplan Strategies conducted in May found that she had by far the highest name recognition among GOP primary voters in the district, with just 3% saying they didn't know who she was. The rest of her opponents hoverered around 50% name recognition.

    The poll also revealed a substantial improvement of her image among GOP voters over time: In February, the same firm found that she had a net unfavorable rating, which she managed to turn around to a net favorable rating by May.

    Of course, the congresswoman also caught a couple of lucky breaks along the way.

    Rather than having to face one candidate head-to-head, she was able to dominate a crowded field of lesser-known candidates. She also caught a lucky break when local Republicans nominated a placeholder candidate to serve out the remainder of retiring Rep. Ken Buck's term, denying a potential advantage to one of her primary opponents.

    On top of all that, Boebert won her old district by less than 600 votes in 2022, and a moderate Democrat backed by an avalanche of money appeared ready to throw her out of Congress this year.

    But all in all, Boebert's primary victory sends a clear signal to other GOP candidates: Engaging in attention-getting tactics can pay off.

    After all, how else would voters in Boebert's new district have known her name if she wasn't constantly appearing on cable news stations, or if she didn't have a massive social media following?

    In an era where both television and social media have contributed to the nationalization of politics — the dissolution of local issues and concerns into a stew of nation narratives — candidates like Boebert can thrive, no matter where they might actually live.

    Read the original article on Business Insider
  • ASX 200 uranium stock tumbles despite significant new production potential

    A man with arms spread yells as he plunges into a swimming pool.

    The S&P/ASX 200 Index (ASX: XJO) is down 0.7% in early trade, with ASX 200 uranium stock Boss Energy Ltd (ASX: BOE) suffering heavier losses.

    Shares in the Aussie uranium producer closed yesterday trading for $3.98. In morning trade on Wednesday, shares are changing hands for $3.84 apiece, down 3.8%.

    Boss Energy isn’t alone in underperforming the benchmark today, with most ASX uranium shares deep in the red this morning.

    And Boss is sliding despite the miner releasing promising drill results from its South Australian satellite project.

    ASX 200 uranium stock tumbles despite promising drill results

    Investors are bidding down the ASX 200 uranium stock today despite the company’s reporting on high-grade drill results at its Gould’s Dam satellite deposit.

    Gould’s Dam is located 80km from the company’s flagship Honeymoon Uranium Mine. The project currently contains a JORC-compliant resource of 25 million pounds (Mlbs) of indicated and inferred U308.

    The ASX 200 uranium stock’s management highlighted that the drill results showed “the potential for Gould’s Dam to help lift Honeymoon’s production rate from the current nameplate capacity of 2.45M lbs a year to the export permit limit of 3.3M lbs a year and/or extend the mine’s useful life”.

    The latest drilling campaign is targeting three areas within the inferred resource envelope at Gould’s Dam – Sunrise, Billeroo and Beulah.

    Infill and step-out drilling at the Sunrise and Billeroo targets is almost complete. To date, 96 mud rotary holes have been drilled for 12,911 metres.

    Uranium mineralisation highlights include:

    • 4.00m @ 2,925ppm pU3O8
    • 3.25m @ 2,230ppm pU3O8
    • 3.25m @ 1,406ppm pU3O8

    The ASX 200 uranium stock said the exploratory program would assist it with wellfield planning and other pre-development work. Work has already commenced on accelerating the development of Gould’s Dam.

    Ongoing exploration will now focus on the Beulah satellite deposit, where Boss Energy plans to drill 40 holes to better define the region’s mineralisation and geological characteristics.

    It will also enable Boss to complete detailed geological and mineralisation models to support the development work and preparation for an ISR Mining Lease proposal for Gould’s Dam.

    According to the release:

    This will lead into the next phase of mine plan development, including pump testing of the mineralised aquifer within the Gould’s Dam Indicated resource (utilising monitoring wells installed during the 2023 drilling campaign) and core sample test work.

    The global Honeymoon Mineral Resource stands at 71.6Mlbs (52.4Mt) with an average grade of 620ppm U308, using a cut-off grade of 250ppm.

    Boss Energy share price snapshot

    Amid growing global nuclear power generation plans, the Boss Energy share price has increased 22% over the past 12 months.

    The ASX 200 uranium stock has lost ground over the past month, though, which sees shares now down 10% in 2024.

    The post ASX 200 uranium stock tumbles despite significant new production potential appeared first on The Motley Fool Australia.

    Should you invest $1,000 in Boss Resources Limited right now?

    Before you buy Boss Resources Limited shares, consider this:

    Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now… and Boss Resources Limited wasn’t one of them.

    The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

    And right now, Scott thinks there are 5 stocks that may be better buys…

    See The 5 Stocks
    *Returns as of 24 June 2024

    More reading

    Motley Fool contributor Bernd Struben has no position in any of the stocks mentioned. The Motley Fool Australia’s parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.